医疗卫生装备

目的：对目前常见的膜式氧合器(以下简称“氧合器”)性能进行仿真分析，从而选出适用体外二氧化碳去除(extracorporeal carbon dioxide removal,ECCO_2R)系统的最佳氧合器。方法：首先，构建圆柱形、方形和盘形3种结构共9个氧合器模型。其次，将氧合器的纤维束定义为多孔介质，设置入口速度为0.3 m/s、出口压力为1 066.56 Pa，采用Realizable k-ε湍流模型进行计算流体动力学(computational fluid dynamics,CFD)仿真，得到各种氧合器的血液流场情况。最后，选取平均速度、出口速度、最大湍流动能、入出口压力差、壁面剪切应力、纤维束面积和厚度7项指标，采用逼近理想解排序(technique for order preference by similarity to ideal solution,TOPSIS)法对9个氧合器的综合性能进行评价。结果：圆柱形氧合器的平均速度、入出口压力差和壁面剪切应力最大，血栓风险最高；方形氧合器居中；盘形氧合器的湍流动能、入出口压力差和壁面剪切应力最小，纤维束面积最大。TOPSIS法评价显示，模型7(盘形氧合器，两侧中部设计独立的进口和出口)综合评分最高，模型1(圆柱形氧合器，底中央设有管状入口，圆柱侧下方设有管状出口)综合评分最低。结论：盘形氧合器最适用ECCO_2R系统。该研究可为氧合器的优化设计与临床选型提供定量依据。

Objective To select the optimal oxygenator for the extracorporeal carbon dioxide removal(ECCO_2R) system based on simulation performance analysis of commonly used membrane oxygenators.Methods First, a total of nine oxygenator models based on three structural configurations were constructed: cylindrical, square, and disc-shaped. Second,the fibre bundles of the oxygenators were regarded as porous media with the inlet velocity set as 0.3 m/s and outlet pressure as 1 066.56 Pa, and computational fluid dynamics(CFD) simulations using the Realizable k-ε turbulence model were carried out to obtain the blood flow fields for various oxygenators. Finally, the comprehensive performance of the nine oxygenators was evaluated with the technique for order preference by similarity to ideal solution(TOPSIS) and seven metrics of average velocity, outlet velocity, maximum turbulent kinetic energy, inlet-outlet pressure difference, wall shear stress, fiber bundle area and thickness.Results The cylindrical oxygenator exhibited the highest average velocity, inletoutlet pressure difference and wall shear stress, and thus posed the highest risk of thrombosis; the square oxygenator ranked in the middle; the disc-shaped oxygenator had the lowest turbulent kinetic energy, inlet-outlet pressure difference and wall shear stress, and the largest fiber bundle area. The TOPSIS evaluation showed that Model 7(disc-shaped oxygenator, with independent inlet and outlet ports designed in the middle of both sides) had the highest overall score, while Model 1(cylindrical oxygenator, with a tubular inlet at the center of the base and a tubular outlet at the lower side of the cylinder)had the lowest overall score.Conclusion The disc-shaped oxygenator is best suited for ECCO_2R system, and quantitative references are provided for the optimized design and clinical selection of oxygenators.[Chinese Medical Equipment Journal,2026,47(4):33-43]